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Folate status in pregnancy is a critical factor in suitable fetal development and women health. Due to the inability to properly process folic acid and food folates, some pregnant women with MTHFR gene polymorphisms have an increased risk to develop deleterious defects. Supplementation with L-Methyl Folate may be the best option to avoid blood folate deficiencies and guarantee the right percentage amount of L-methylfolate in fetal blood as it provides the “natural” and “bioactive” dose of folate, without metabolization by MTHFR.
Vitamin B6 might play a role in the prevention of pre-eclampsia and possibly preterm birth. Recent reviews of the literature indicate, however, that there is insufficient evidence on the benefits and harms, if any, of routine vitamin B6 (pyridoxine) supplementation during pregnancy, though it may provide some relief from pregnancy-related nausea.
Vitamin B12 is crucial for normal cell division and differentiation, and necessary for the development and myelination of the central nervous system. Pregnant mothers in resource poor settings are at risk for poor vitamin B12 status. Poor vitamin B12 status in infancy is linked to poor growth and neuro development. Brain development starts from conception, and pregnancy is a period of rapid growth and development for the brain.
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